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Quizzing the Anonymous - Why does the plague kill?
March 2nd, 2010
12:53 am

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Why does the plague kill?

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From:shkrobius
Date:March 8th, 2010 02:36 am (UTC)

Re: Интереснее проследить "молниеносность"

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Y. pestis kills macrophages by caspase-1 activation. This is not exceptional, Legionella also uses this activation path, hepatitis C viruses, adenoviruses, infuenza A, etc. also activate caspases. It is a very common way of killing a cell. By this acount, a huge number of bacteria can be regarded as preadapted as macrophage destroyers. The ability to survive in phagosomes is also common, so is the ability to make biofilms. I think if you make this argument consistently, you will conclude that the great majority of soil gram-negative bacteria are preadapted in the same sense Y. pestis and Ypt are preadapted. So this can't be the answer to "why does Y. pestis kill?" In the soil, it is an odinary bacterium with unexceptional skills.
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